Protein Modification Reagents
Medchemexpress LLC Azide-PEG-amine | 95.0% | 25 MG
Azide-PEG-amine (MW 2000) is a PEG-based PROTAC linker, essential for synthesizing PROTACs. It acts as a versatile click chemistry reagent, featuring an azide group. This enables its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. PROTACs utilize this linker to connect ligands, targeting E3 ubiquitin ligase and a protein of interest for selective degradation. This product is for research use only.
- PEG-based PROTAC linker for PROTAC synthesis
- Functions as a click chemistry reagent with an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Supports strain-promoted alkyne-azide cycloaddition (SPAAC)
- Leverages ubiquitin-proteasome system for selective protein degradation
- Intended for research use only
Avanti Polar Lipids DSPE-PEG(2000) AZIDE 50MG
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[azido(polyethylene glycol)-2000] (ammonium salt) 50mg
Medchemexpress LLC Dbco-peg4-val-cit-pab-pnp | 2226472-28-0 | 98.3% | 1079.16 | C55H66N8O15 | 100 MG
DBCO-PEG4-Val-Cit-PAB-PNP is a cleavable linker reagent designed for constructing antibody-drug conjugates and click-chemistry bioconjugates. It combines a strain-promoted alkyne-azide cycloaddition (DBCO) handle with a Val-Cit protease-cleavable dipeptide and a PAB-PNP leaving group to enable enzyme-triggered payload release and efficient payload attachment. The compound is supplied as a characterized solid for research use.
Medchemexpress LLC PEG(2000)-C-DMG | 1443687-74-8 | 98.0% | 2600 g/mol (approx.) | 10 MG
PEG(2000)-C-DMG is a polyethylene glycol-conjugated lipid used as a PEG-lipid component in liposomes and lipid nanoparticles (LNPs). It helps stabilize particle surfaces, reduce protein adsorption, and modulate circulation time for nucleic acid delivery applications such as siRNA and mRNA formulations. Typical form is a white to off-white solid with solubility in DMSO (requires sonication).
- Improves particle stability and circulation time.
- Reduces serum protein adsorption and aggregation.
- Suitable for lipid nanoparticle and liposome formulations for nucleic acid delivery.
- Supplied as a solid that is soluble in DMSO with sonication.
- High purity for research applications.
Medchemexpress LLC DSPE-PEG-DBCO sodium | 99.6% | 3400 (average) | 5 MG
DSPE-PEG-DBCO sodium (MW 3400) is a DBCO-functionalized PEGylated phospholipid supplied as a white to off-white solid. It provides a bioorthogonal DBCO handle for strain-promoted azide-alkyne cycloaddition (SPAAC) and an amphiphilic DSPE-PEG backbone suitable for incorporation into liposomes and lipid nanoparticles for surface functionalization and delivery research.
- Provides DBCO handle for copper-free click conjugation.
- Enables surface functionalization of liposomes and nanoparticles.
- Amphiphilic PEG-lipid backbone supports stable lipid formulations.
- PEG chain (average MW 3400) imparts steric stabilization and solubility.
- Supplied as a solid suitable for small-scale research use.
- Available in small packaged quantities for laboratory experiments.
eMolecules 14-(Amine-PEG5-ethylcarbamoyl)tridecanoic-t-butyl ester | Broadpharm |576.816 | C30H60N2O8 | 95.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCC(=O)NCCOCCOCCOCCOCCOCCN | 100mg | 784455389
14-(Amine-PEG5-ethylcarbamoyl)tridecanoic-t-butyl ester | Broadpharm |576.816 | C30H60N2O8 | 95.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCC(=O)NCCOCCOCCOCCOCCOCCN | 100mg | 784455389